The Nimzo-Indian Defense reaction to 1.d4 2. c4 3.Nc3 is likely the best Black Defense. There are many die hard Gruenfeld and Slav Defense players who would vehemently contest this claim, but Super GMs such as Anatoly Karpov and Michael Adams play move orders that avoid the Nimzo-Indian which is characterized by Bb4 pinning the c3 Knight and "threatening pawn doubling".
In the diagrammed position, BIV of the United States playing at the ICC, ill-advisedly played Bishop captures Knight without being provoked by a3. The drawback to the premature capture, giving up the mini exchange according to Fischer, is that White has not blocked his f-pawn with Nf3. The f pawn can spearhead a line-opening attack against the Black King. The lines being the f file and the c1-h6 diagonal.
Also the e2 White Knight can become fatally aggressive by hopping to g3 and h5 accentuating the pinned Black Horse at f6.
Black greedily went after one of the doubled c pawns at c4 by misplacing his Knight at a5 millions of miles from the King Side where it might play a defensive role. The materialist plan of winning the the c4 pawn with the aforementioned Knight and Bishop to a6 is unsound as proved in this game where Black was crushed to death by a merciless White attack for his greedy forays on the other side of the board!
GM Roman Dzindzichashvili, who was sort of a sleazy, Bohemian, con-artist type back in the 80s and early 90s at many United States USCF tournaments, has written some excellent stuff regarding the demerits of capturing at c3 too early in the Nimzo-Indian.
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